CSMD2

Across TCGA patient cohorts, CSMD2 mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSMD2-associated genes across cancer lineages are FASN, PCNA, and 4E-BP1. Each is linked with CSMD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CSMD2-to-partner and partner-to-CSMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CSMD2-low versus CSMD2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSMD2→partner) and Y-score (partner→CSMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.262	+2.015	.042	.016	3	5
LUAD	PCNA →	+0.204	+2.087	<.001	.004	3	5
LUSC	4E-BP1 →	+0.271	+1.847	.004	.005	3	4
LUAD	Cyclin-B1 →	+0.566	+2.906	<.001	.001	3	4
LUSC	MYH11 →	-0.681	-2.502	.003	.001	3	4
LUSC	Claudin-7 →	+0.282	+1.584	.018	.013	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

FASN by CSMD2 expression — STAD

Explore this box plot interactively →