CSMD2

Across TCGA cell cohorts, CSMD2 mutation is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSMD2-associated genes across cancer lineages are METTL21A, MRPL39, and TTC39B. Each is linked with CSMD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSMD2-to-partner and partner-to-CSMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL21A grouped by CSMD2-low versus CSMD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSMD2→partner) and Y-score (partner→CSMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL21A →	+0.450	+1.628	.006	<.001	3	3
LARGE_INTESTINE	MRPL39 →	+0.551	+2.782	<.001	<.001	3	3
STOMACH	TTC39B →	+0.936	+3.392	.005	.001	3	3
BLOOD_Leukemia	CMC2 →	+0.508	+3.518	<.001	<.001	3	3
BLOOD_Leukemia	NDUFA9 →	+0.611	+2.837	<.001	<.001	3	3
LUNG_SCLC	AATF →	+0.579	+2.459	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

METTL21A by CSMD2 expression — LARGE_INTESTINE

Explore this box plot interactively →