CSK

Across TCGA pan-cancer cohorts, CSK mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CSK data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CSK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CSK expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

COAD, UCEC, and LUAD are the cancer types where CSK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.865	1.000	.009	102	view →
UCEC	OS	Median	All	1.000	0.906	.008	36	view →
LUAD	DFS	Tertile	All	0.865	0.460	.001	17	view →
HNSC	DFS	Tertile	II,III,IV	0.915	1.000	.009	10	view →
CCRCC	OS	Median	All	0.602	0.985	.009	7	view →
GBM	DFS	Quartile	All	0.211	0.381	.007	6	view →
PDAC	OS	Tertile	All	0.568	0.342	.038	3	view →
LSCC	DFS	Median	All	0.929	0.615	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CSK–COAD (DFS)

Open the COAD breakdown →