CSK

Across TCGA cell cohorts, CSK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,019 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CSK-associated GO terms across cancer lineages are DNA replication proofreading, DNA replication-dependent chromatin assembly, and Positive regulation of DNA-templated DNA replication. Each is linked with CSK in more than 13 cancer types. Because this analysis shows association rather than direction, both CSK-to-partner and partner-to-CSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by CSK-low versus CSK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CSK→partner) and Y-score (partner→CSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication proofreading →	+0.224	+0.678	.005	.004	3	14
CNS	DNA replication-dependent chromatin assembly →	+0.087	+0.579	.001	<.001	3	13
BONE	Positive regulation of DNA-templated DNA replication →	+0.124	+0.556	.002	.008	3	13
SKIN	Positive regulation of nuclear cell cycle DNA replication →	+0.081	+0.622	.003	.004	3	12
SKIN	Cellular response to cisplatin →	+0.141	+0.738	<.001	.001	3	12
PANCREAS	DNA replication checkpoint signaling →	+0.113	+0.469	.002	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,019 associations by consensus.

DNA replication proofreading by CSK expression — BONE

Explore this box plot interactively →