CSK

Across TCGA cell cohorts, CSK mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSK-associated genes across cancer lineages are CLDN34, CBLN4, and GSG1L2. Each is linked with CSK in more than 1 cancer types. Because this analysis shows association rather than direction, both CSK-to-partner and partner-to-CSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN34 grouped by CSK-low versus CSK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSK→partner) and Y-score (partner→CSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLDN34 →	+0.067	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
STOMACH	KRTAP9-4 →	+0.040	+5.285	<.001	.003	3	1
BLOOD_Leukemia	MYPN →	+0.031	+4.152	<.001	.009	1	1
BLOOD_Leukemia	SMIM32 →	+0.023	+4.169	.004	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLDN34 by CSK expression — BLOOD_Leukemia

Explore this box plot interactively →