Across TCGA patient cohorts, CSHL1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSHL1-associated genes across cancer lineages are Caspase-7-cleavedD198, p90 RSK_pT359_S363, and PDCD4. Each is linked with CSHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSHL1-to-partner and partner-to-CSHL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSHL1→partner) and Y-score (partner→CSHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.909	+2.522	<.001	<.001	3	3
UCEC	p90 RSK_pT359_S363 →	-0.150	-1.874	.035	.049	3	2
UCEC	PDCD4 →	-0.702	-2.906	<.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.107	-2.321	.003	.005	3	2
UCEC	Caspase-8 →	-0.236	-2.388	.007	.002	3	2
SKCM	p21 →	-0.588	-3.000	.003	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

CSHL1 survival (RNA) · tumor vs normal (RNA) · all CSHL1 data types