Across TCGA cell cohorts, CSHL1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CSHL1-associated genes across cancer lineages are FAM187B, OR52E2, and MS4A13. Each is linked with CSHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSHL1-to-partner and partner-to-CSHL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSHL1→partner) and Y-score (partner→CSHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM187B →	+0.027	+3.347	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.341	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.207	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB133 →	+0.084	+5.228	.003	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

CSHL1 survival (RNA) · tumor vs normal (RNA) · all CSHL1 data types