Across TCGA patient cohorts, CSH2 mutation is significantly associated with the RNA expression of many other genes, with 637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSH2-associated genes across cancer lineages are MIR7702, PPP1R26P4, and VN1R54P. Each is linked with CSH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSH2-to-partner and partner-to-CSH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSH2→partner) and Y-score (partner→CSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.245	+4.360	<.001	.004	3	2
SKCM	PPP1R26P4 →	+0.007	+3.071	<.001	.001	3	2
LUAD	VN1R54P →	+0.921	+4.055	<.001	.005	3	2
LUAD	RNA5SP66 →	+0.336	+4.399	<.001	.008	3	2
UCEC	DHRS11 →	+0.565	+2.711	.002	.003	3	2
UCEC	VARS2 →	+0.403	+2.711	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 637 associations by consensus.

Exploration

CSH2 survival (RNA) · tumor vs normal (RNA) · all CSH2 data types