CSF3R

Across TCGA patient cohorts, CSF3R mutation is significantly associated with the RNA expression of many other genes, with 3,016 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF3R-associated genes across cancer lineages are RPARP-AS1, LINS1, and NARS1. Each is linked with CSF3R in more than 4 cancer types. Because this analysis shows association rather than direction, both CSF3R-to-partner and partner-to-CSF3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPARP-AS1 grouped by CSF3R-low versus CSF3R-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF3R→partner) and Y-score (partner→CSF3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPARP-AS1 →	+0.627	+3.345	<.001	.005	2	5
UCEC	LINS1 →	+0.261	+3.743	.002	<.001	3	4
COAD	NARS1 →	+0.617	+3.486	<.001	.002	3	3
COAD	VANGL2 →	-1.379	-3.459	<.001	.005	3	3
COAD	ZNF367 →	+0.563	+3.513	.007	.002	3	3
COAD	MTHFD2 →	+0.782	+3.196	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,016 associations by consensus.

RPARP-AS1 by CSF3R expression — LUSC

Explore this box plot interactively →