CSF3R

Across TCGA patient cohorts, CSF3R mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF3R-associated genes across cancer lineages are ERK2, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with CSF3R in more than 2 cancer types. Because this analysis shows association rather than direction, both CSF3R-to-partner and partner-to-CSF3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CSF3R-low versus CSF3R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF3R→partner) and Y-score (partner→CSF3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.130	+1.807	.031	.024	3	3
COAD	Shc_pY317 →	-0.236	-3.157	.001	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.509	+3.016	<.001	.018	3	3
COAD	ASNS →	+0.738	+2.330	<.001	.020	3	3
STAD	CD31 →	-0.202	-3.000	.012	.036	3	2
COAD	14-3-3_beta →	-0.202	-3.433	.028	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ERK2 by CSF3R expression — UCEC

Explore this box plot interactively →