CSDE1

Across TCGA cell cohorts, CSDE1 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CSDE1-associated genes across cancer lineages are HSD3B2, RCHY1, and TSPY3. Each is linked with CSDE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSDE1-to-partner and partner-to-CSDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD3B2 grouped by CSDE1-low versus CSDE1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSDE1→partner) and Y-score (partner→CSDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HSD3B2 →	+0.117	+2.864	<.001	.009	3	2
LARGE_INTESTINE	RCHY1 →	+0.719	+3.169	.002	.006	3	2
LUNG_SCLC	TSPY3 →	+0.649	+4.269	.001	.005	3	1
LUNG_SCLC	TSPY8 →	+0.797	+4.044	<.001	.009	3	1
LUNG_SCLC	RBMY1A1 →	+1.377	+4.044	<.001	.009	3	1
LUNG_SCLC	RBMY1E →	+1.140	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

HSD3B2 by CSDE1 expression — CNS

Explore this box plot interactively →