CSAD

Across TCGA patient cohorts, CSAD mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSAD-associated genes across cancer lineages are cIAP, C-Raf, and 14-3-3_beta. Each is linked with CSAD in more than 1 cancer types. Because this analysis shows association rather than direction, both CSAD-to-partner and partner-to-CSAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by CSAD-low versus CSAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSAD→partner) and Y-score (partner→CSAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.118	+2.331	.037	.019	3	2
UCEC	C-Raf →	+0.144	+2.584	.015	.010	3	2
UCEC	14-3-3_beta →	-0.096	-3.143	.020	.018	3	1
UCEC	EGFR_pY1068 →	-0.224	-1.807	.031	.027	3	1
UCEC	eIF4E →	+0.205	+2.321	.018	.006	3	1
UCEC	A-Raf_pS299 →	-0.138	-2.321	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

cIAP by CSAD expression — UCEC

Explore this box plot interactively →