CRYZL2P

Across TCGA pan-cancer cohorts, CRYZL2P RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CRYZL2P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CRYZL2P RNA is repressed in tumor relative to normal tissue. In most cancer types CRYZL2P is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, STAD, and KIRP are the cancer types where CRYZL2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYZL2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.990	<.001	11	view →
STAD	Male	II,III,IV	+1.422	<.001	9	view →
KIRP	All	III,IV	−1.117	.001	8	view →
LIHC	Male	All	+1.053	<.001	8	view →
LUSC	Male	II,III,IV	−0.798	<.001	7	view →
BRCA	All	III,IV	−0.841	<.001	6	view →
CHOL	All	All	+1.682	<.001	5	view →
READ	Female	All	+1.932	.003	2	view →
COAD	All	All	+0.471	.021	2	view →
KIRC	Female	All	+0.435	.010	2	view →
PRAD	All	All	−0.274	.037	2	view →
LUAD	All	All	−0.220	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CRYZL2P–KICH

Open the KICH breakdown →