CRYZ

Across TCGA patient cohorts, CRYZ mutation is significantly associated with the RNA expression of many other genes, with 3,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYZ-associated genes across cancer lineages are DNAJC8, RNU1-17P, and RN7SKP257. Each is linked with CRYZ in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYZ-to-partner and partner-to-CRYZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC8 grouped by CRYZ-low versus CRYZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYZ→partner) and Y-score (partner→CRYZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJC8 →	+0.510	+4.413	<.001	<.001	3	3
UCEC	RNU1-17P →	+0.213	+2.520	<.001	.001	3	3
SKCM	RN7SKP257 →	+0.050	+5.003	<.001	.002	3	2
SKCM	LINC02647 →	+0.051	+6.009	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.688	+3.332	<.001	<.001	3	2
UCEC	GUF1 →	+0.624	+2.673	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,001 associations by consensus.

DNAJC8 by CRYZ expression — UCEC

Explore this box plot interactively →