CRYZ

Across TCGA pan-cancer cohorts, CRYZ RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CRYZ’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CRYZ RNA is repressed in tumor relative to normal tissue. In most cancer types CRYZ is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and KIRP are the cancer types where CRYZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−4.144	<.001	11	view →
LUSC	All	All	−0.650	<.001	6	view →
KIRP	All	III,IV	−0.541	.002	5	view →
COAD	Male	All	+0.665	.008	4	view →
THCA	All	All	−0.416	<.001	4	view →
PRAD	All	All	−0.794	<.001	2	view →
UCEC	All	All	−0.564	.010	2	view →
LIHC	Male	All	+0.542	.003	2	view →
LUAD	All	All	+0.276	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CRYZ–KICH

Open the KICH breakdown →