CRYZ

Across TCGA cell cohorts, CRYZ mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYZ-associated genes across cancer lineages are TSHB, TRIM60, and TEX101. Each is linked with CRYZ in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYZ-to-partner and partner-to-CRYZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by CRYZ-low versus CRYZ-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYZ→partner) and Y-score (partner→CRYZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSHB →	+0.057	+4.832	.001	.002	3	1
CNS	TRIM60 →	+0.005	+5.357	<.001	.001	3	1
LARGE_INTESTINE	TEX101 →	+0.229	+3.708	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.210	+3.425	.003	<.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TSHB by CRYZ expression — CNS

Explore this box plot interactively →