Across TCGA patient cohorts, CRYGS mutation is significantly associated with the RNA expression of many other genes, with 1,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGS-associated genes across cancer lineages are RN7SL248P, RNA5SP113, and MRPL49P1. Each is linked with CRYGS in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGS-to-partner and partner-to-CRYGS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGS→partner) and Y-score (partner→CRYGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.067	+3.400	<.001	.003	3	2
UCEC	RNA5SP113 →	+0.466	+2.904	<.001	.009	3	2
LUAD	MRPL49P1 →	+0.094	+5.523	<.001	.001	3	2
SKCM	RNU6-1318P →	+0.320	+4.292	<.001	.001	3	2
SKCM	NPM1P51 →	+0.151	+3.657	<.001	.007	3	2
BLCA	RNU6-1174P →	+0.367	+5.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,111 associations by consensus.

Exploration

CRYGS survival (RNA) · tumor vs normal (RNA) · all CRYGS data types