Across TCGA pan-cancer cohorts, CRYGFP RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CRYGFP’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CRYGFP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRYGFP is over-expressed in tumor.
LUSC are the cancer types where CRYGFP tumor–normal differential expression is most reproducible.