CRYGC

Across TCGA patient cohorts, CRYGC mutation is significantly associated with the RNA expression of many other genes, with 268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGC-associated genes across cancer lineages are DHFRP2, RPS26P30, and RPS29P26. Each is linked with CRYGC in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGC-to-partner and partner-to-CRYGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHFRP2 grouped by CRYGC-low versus CRYGC-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGC→partner) and Y-score (partner→CRYGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DHFRP2 →	+0.124	+3.116	<.001	.003	3	2
LUSC	RPS26P30 →	+0.181	+5.038	<.001	.009	3	2
LUAD	RPS29P26 →	+0.203	+6.345	<.001	<.001	3	2
UCEC	C9orf153 →	+0.182	+3.518	.001	.004	3	2
UCEC	VDAC1P8 →	+0.509	+3.375	<.001	.004	3	2
UCEC	MYL12BP1 →	+0.516	+3.375	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 268 associations by consensus.

DHFRP2 by CRYGC expression — LUAD

Explore this box plot interactively →