Across TCGA pan-cancer cohorts, CRYGC RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CRYGC’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRYGC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRYGC is over-expressed in tumor.
HNSC and LUAD are the cancer types where CRYGC tumor–normal differential expression is most reproducible.