CRYGC

Across TCGA patient cohorts, CRYGC mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGC-associated genes across cancer lineages are Cyclin-E2, Bak, and eIF4G. Each is linked with CRYGC in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGC-to-partner and partner-to-CRYGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CRYGC-low versus CRYGC-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGC→partner) and Y-score (partner→CRYGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E2 →	+0.374	+2.824	<.001	.036	3	2
LUAD	Bak →	+0.138	+2.841	.026	.035	3	1
UCEC	eIF4G →	+0.476	+2.999	.005	.035	3	1
UCEC	STAT3_pY705 →	-0.682	-2.999	<.001	.035	3	1
UCEC	JNK2 →	+0.288	+3.169	.008	.020	2	1
UCEC	beta-Catenin →	+0.601	+3.169	.030	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Cyclin-E2 by CRYGC expression — LUAD

Explore this box plot interactively →