CRYGC

Across TCGA cell cohorts, CRYGC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYGC-associated genes across cancer lineages are DIRC1, MINDY4B, and IQCF5. Each is linked with CRYGC in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGC-to-partner and partner-to-CRYGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIRC1 grouped by CRYGC-low versus CRYGC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGC→partner) and Y-score (partner→CRYGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DIRC1 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	MINDY4B →	+0.029	+5.415	<.001	.004	3	1
BLOOD_Leukemia	IQCF5 →	+0.104	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DIRC1 by CRYGC expression — LARGE_INTESTINE

Explore this box plot interactively →