CRYBB3

Across TCGA patient cohorts, CRYBB3 mutation is significantly associated with the RNA expression of many other genes, with 389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBB3-associated genes across cancer lineages are KRT18P50, MRPL51P2, and GCC1. Each is linked with CRYBB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB3-to-partner and partner-to-CRYBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT18P50 grouped by CRYBB3-low versus CRYBB3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB3→partner) and Y-score (partner→CRYBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT18P50 →	+0.048	+4.952	<.001	.002	3	1
STAD	MRPL51P2 →	+0.135	+3.902	.002	.007	3	1
UCEC	GCC1 →	+0.608	+3.202	.003	.009	3	1
UCEC	FTMT →	+0.203	+2.434	<.001	.005	3	1
UCEC	KMT5A →	+0.503	+3.470	.003	.003	3	1
UCEC	ATL3 →	+0.735	+3.332	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 389 associations by consensus.

KRT18P50 by CRYBB3 expression — HNSC

Explore this box plot interactively →