CRYBB2

Across TCGA patient cohorts, CRYBB2 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CRYBB2-associated genes across cancer lineages are ZBTB8OS, H2BL1P, and MRPS35P2. Each is linked with CRYBB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB2-to-partner and partner-to-CRYBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB8OS grouped by CRYBB2-low versus CRYBB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB2→partner) and Y-score (partner→CRYBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZBTB8OS →	+0.484	+3.232	.001	.008	3	2
SKCM	H2BL1P →	+0.029	+4.421	<.001	.003	3	2
SKCM	MRPS35P2 →	+0.070	+4.369	<.001	<.001	3	2
SKCM	LINC00239 →	+1.076	+3.522	<.001	.002	3	2
SKCM	HNRNPCP1 →	+0.625	+2.839	.001	.001	3	2
SKCM	LINC02340 →	+0.433	+2.189	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

ZBTB8OS by CRYBB2 expression — SKCM

Explore this box plot interactively →