CRYBB1

Across TCGA patient cohorts, CRYBB1 mutation is significantly associated with the RNA expression of many other genes, with 1,052 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBB1-associated genes across cancer lineages are GTSE1-DT, POLE2, and MRPL37. Each is linked with CRYBB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBB1-to-partner and partner-to-CRYBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTSE1-DT grouped by CRYBB1-low versus CRYBB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB1→partner) and Y-score (partner→CRYBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GTSE1-DT →	+0.395	+2.818	.002	.001	3	2
UCEC	POLE2 →	+0.539	+3.191	.008	.009	3	2
UCEC	MRPL37 →	+0.535	+3.507	.002	.002	3	2
UCEC	DHDDS →	+0.432	+3.354	.001	.005	3	2
UCEC	LRRC47 →	+0.390	+3.364	.006	.004	3	2
UCEC	DCUN1D5 →	+0.553	+2.807	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,052 associations by consensus.

GTSE1-DT by CRYBB1 expression — UCEC

Explore this box plot interactively →