CRYBB1

Across TCGA cell cohorts, CRYBB1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYBB1-associated genes across cancer lineages are MMP26, TBC1D3, and OR10V1. Each is linked with CRYBB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB1-to-partner and partner-to-CRYBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by CRYBB1-low versus CRYBB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB1→partner) and Y-score (partner→CRYBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.060	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D3 →	+0.088	+4.273	<.001	.006	3	1
STOMACH	OR10V1 →	+0.036	+5.285	<.001	.003	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
SKIN	ANKRD30BL →	+0.050	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MMP26 by CRYBB1 expression — LARGE_INTESTINE

Explore this box plot interactively →