Across TCGA patient cohorts, CRYBA4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBA4-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and MEK1. Each is linked with CRYBA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBA4-to-partner and partner-to-CRYBA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA4→partner) and Y-score (partner→CRYBA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.261	+2.415	<.001	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.164	-1.893	.015	.016	3	1
UCEC	MEK1 →	+0.491	+3.700	<.001	.001	3	1
UCEC	MSH6 →	-0.417	-1.874	.001	.049	3	1
UCEC	Myosin-IIa →	+0.166	+2.229	.035	.006	3	1
UCEC	Notch1 →	+0.193	+2.710	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

CRYBA4 survival (RNA) · tumor vs normal (RNA) · all CRYBA4 data types