Across TCGA pan-cancer cohorts, CRYBA4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRYBA4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CRYBA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRYBA4 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

COAD, BRCA, and UCEC are the cancer types where CRYBA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYBA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.544	<.001	4	view →
BRCA	All	All	+0.134	<.001	4	view →
UCEC	All	All	+1.061	.007	2	view →
KIRP	Male	All	−0.139	.002	1	view →
KICH	All	All	−0.102	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CRYBA4 RNA expression & survival · all CRYBA4 data types