CRYBA2

Across TCGA patient cohorts, CRYBA2 mutation is significantly associated with the RNA expression of many other genes, with 870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBA2-associated genes across cancer lineages are MRPL57P6, RNU6-284P, and MIR5092. Each is linked with CRYBA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBA2-to-partner and partner-to-CRYBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL57P6 grouped by CRYBA2-low versus CRYBA2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA2→partner) and Y-score (partner→CRYBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPL57P6 →	+0.199	+7.930	<.001	.008	3	3
STAD	RNU6-284P →	+0.270	+4.798	<.001	.006	3	3
SKCM	MIR5092 →	+0.371	+4.594	<.001	.008	3	2
SKCM	RN7SL820P →	+0.338	+4.595	<.001	.004	3	2
COAD	RNY3P5 →	+0.372	+6.409	<.001	<.001	3	2
COAD	TRAJ52 →	+1.405	+4.754	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 870 associations by consensus.

MRPL57P6 by CRYBA2 expression — LUAD

Explore this box plot interactively →