CRYBA2

Across TCGA patient cohorts, CRYBA2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBA2-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PAI-1. Each is linked with CRYBA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBA2-to-partner and partner-to-CRYBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CRYBA2-low versus CRYBA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA2→partner) and Y-score (partner→CRYBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.496	+3.000	.018	.037	3	1
UCEC	p62 Lck ligand →	+0.513	+3.000	.006	.037	3	1
UCEC	PAI-1 →	+0.523	+3.000	.008	.037	2	2
UCEC	Shc_pY317 →	-0.209	-3.000	.017	.036	3	1
UCEC	PCNA →	+0.257	+3.000	.039	.037	2	1
UCEC	Rad50 →	-0.288	-3.000	.040	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by CRYBA2 expression — UCEC

Explore this box plot interactively →