CRYBA2

Across TCGA cell cohorts, CRYBA2 mutation is significantly associated with the mutation status of many other genes, with 1,444 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYBA2-associated genes across cancer lineages are RAB11FIP4, ILDR2, and EPHA7. Each is linked with CRYBA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBA2-to-partner and partner-to-CRYBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB11FIP4 grouped by CRYBA2-low versus CRYBA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA2→partner) and Y-score (partner→CRYBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB11FIP4 →	+2.865	+4.217	.007	.007	1	3
CNS	ILDR2 →	+4.044	+5.000	.008	.008	1	3
BLOOD_Lymphoma	EPHA7 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	VPS39 →	+4.429	+5.247	.005	.005	1	2
BLOOD_Lymphoma	ZBTB2 →	+6.014	+6.014	.001	.001	1	2
BLOOD_Lymphoma	EFHC2 →	+5.014	+5.584	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,444 associations by consensus.

RAB11FIP4 by CRYBA2 expression — LARGE_INTESTINE

Explore this box plot interactively →