CRYAB

Across TCGA patient cohorts, CRYAB mutation is significantly associated with the RNA expression of many other genes, with 293 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYAB-associated genes across cancer lineages are EI24P4, FABP5P12, and IGHVIII-67-4. Each is linked with CRYAB in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYAB-to-partner and partner-to-CRYAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EI24P4 grouped by CRYAB-low versus CRYAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYAB→partner) and Y-score (partner→CRYAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EI24P4 →	+0.088	+2.436	.004	.003	3	2
UCEC	FABP5P12 →	+0.117	+2.677	<.001	.002	3	2
COAD	IGHVIII-67-4 →	+0.168	+5.790	.004	.003	3	2
BRCA	RNU7-153P →	+0.741	+8.055	<.001	.007	3	1
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1
UCEC	CCL5 →	+1.303	+3.475	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 293 associations by consensus.

EI24P4 by CRYAB expression — UCEC

Explore this box plot interactively →