CRYAB

Across TCGA pan-cancer cohorts, CRYAB RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CRYAB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CRYAB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRYAB is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

KIRC, BLCA, and THCA are the cancer types where CRYAB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYAB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.546	<.001	12	view →
BLCA	Male	III,IV	−5.194	<.001	11	view →
THCA	Male	All	−1.961	<.001	11	view →
COAD	Male	All	−2.150	<.001	10	view →
LUAD	Female	III,IV	−2.536	<.001	9	view →
KIRP	Female	All	+2.221	<.001	9	view →
STAD	Female	All	−2.714	<.001	8	view →
HNSC	Male	All	−2.114	<.001	8	view →
KICH	Female	II,III,IV	−4.345	<.001	7	view →
BRCA	All	III,IV	−4.566	<.001	6	view →
UCEC	All	All	−2.607	<.001	6	view →
LIHC	Male	II,III,IV	+1.734	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CRYAB–KIRC

Open the KIRC breakdown →