CRYAB

Across TCGA patient cohorts, CRYAB mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYAB-associated genes across cancer lineages are JNK_pT183_Y185, Annexin-1, and Rad50. Each is linked with CRYAB in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYAB-to-partner and partner-to-CRYAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CRYAB-low versus CRYAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYAB→partner) and Y-score (partner→CRYAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.176	-2.446	.030	.020	3	1
UCEC	Annexin-1 →	+0.585	+3.019	.021	.019	3	1
UCEC	Rad50 →	-0.316	-3.169	.006	.019	2	1
UCEC	eEF2K →	+0.372	+2.472	.027	.011	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

JNK_pT183_Y185 by CRYAB expression — UCEC

Explore this box plot interactively →