CRYAB

Across TCGA cell cohorts, CRYAB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,426 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CRYAB-associated GO terms across cancer lineages are ERAD pathway, Negative regulation of protein-containing complex assembly, and Negative regulation of myoblast fusion. Each is linked with CRYAB in more than 7 cancer types. Because this analysis shows association rather than direction, both CRYAB-to-partner and partner-to-CRYAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by CRYAB-low versus CRYAB-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYAB→partner) and Y-score (partner→CRYAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ERAD pathway →	+0.060	+2.945	<.001	.002	3	8
BONE	Negative regulation of protein-containing complex assembly →	+0.114	+5.096	<.001	<.001	3	7
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.086	+0.545	.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Potassium ion transmembrane transport →	-0.051	-2.325	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of proteasomal protein catabolic process →	+0.072	+2.742	<.001	<.001	3	7
KIDNEY	Endosome organization →	+0.069	+3.400	.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,426 associations by consensus.

ERAD pathway by CRYAB expression — SKIN

Explore this box plot interactively →