CRYAA

Across TCGA patient cohorts, CRYAA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,845 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CRYAA-associated GO terms across cancer lineages are Mitotic sister chromatid separation, Cytoplasmic microtubule organization, and Cellular response to radiation. Each is linked with CRYAA in more than 6 cancer types. Because this analysis shows association rather than direction, both CRYAA-to-partner and partner-to-CRYAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid separation grouped by CRYAA-low versus CRYAA-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYAA→partner) and Y-score (partner→CRYAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Mitotic sister chromatid separation →	+0.060	+0.021	<.001	<.001	3	7
STAD	Cytoplasmic microtubule organization →	+0.037	+0.014	<.001	<.001	3	7
ESCA	Cellular response to radiation →	+0.049	+0.018	.001	.001	3	6
STAD	Extrinsic apoptotic signaling pathway →	+0.046	+0.013	<.001	<.001	3	6
ESCA	Regulation of chromosome organization →	+0.057	+0.020	.001	<.001	2	7
SCLC	Obsolete histone methylation →	+0.147	+0.307	.001	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,845 associations by consensus.

Mitotic sister chromatid separation by CRYAA expression — ESCA

Explore this box plot interactively →