CRYAA

Across TCGA pan-cancer cohorts, CRYAA RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CRYAA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CRYAA RNA is repressed in tumor relative to normal tissue. In most cancer types CRYAA is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where CRYAA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYAA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.755	<.001	9	view →
KICH	All	All	−0.481	.001	5	view →
KIRC	All	III,IV	−0.421	.001	5	view →
LIHC	Male	II,III,IV	−0.075	.019	2	view →
LUSC	Male	II,III,IV	−0.008	.035	2	view →
HNSC	All	II,III,IV	+0.007	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CRYAA–KIRP

Open the KIRP breakdown →