CRYAA

Across TCGA cell cohorts, CRYAA mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CRYAA-associated genes across cancer lineages are OR6K6, MBD3L5, and GH1. Each is linked with CRYAA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYAA-to-partner and partner-to-CRYAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K6 grouped by CRYAA-low versus CRYAA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYAA→partner) and Y-score (partner→CRYAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6K6 →	+0.014	+4.415	.001	.007	3	1
SKIN	MBD3L5 →	+0.016	+4.415	<.001	.007	3	1
SKIN	GH1 →	+0.036	+4.415	<.001	.007	3	1
SKIN	CCL14 →	+0.075	+4.095	.006	.009	3	1
SKIN	AMELY →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR6K6 by CRYAA expression — SKIN

Explore this box plot interactively →