CRTAP

Across TCGA patient cohorts, CRTAP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTAP-associated genes across cancer lineages are eEF2, ERK2, and GSK3-a-b. Each is linked with CRTAP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTAP-to-partner and partner-to-CRTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CRTAP-low versus CRTAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTAP→partner) and Y-score (partner→CRTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.572	+3.169	<.001	.018	3	1
UCEC	ERK2 →	+0.231	+3.169	.013	.019	3	1
UCEC	GSK3-a-b →	+0.166	+2.999	.011	.035	3	1
UCEC	JNK2 →	+0.202	+2.459	.035	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.517	-3.000	.022	.036	3	1
UCEC	MEK1 →	+0.588	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eEF2 by CRTAP expression — UCEC

Explore this box plot interactively →