CRTAM

Across TCGA patient cohorts, CRTAM mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTAM-associated genes across cancer lineages are Notch1, Stathmin, and ATM. Each is linked with CRTAM in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTAM-to-partner and partner-to-CRTAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CRTAM-low versus CRTAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTAM→partner) and Y-score (partner→CRTAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.209	+3.817	<.001	<.001	3	2
UCEC	Stathmin →	+0.113	+1.415	.027	.046	3	2
UCEC	ATM →	-0.679	-2.169	<.001	.003	3	2
UCEC	c-Met_pY1235 →	+0.056	+1.594	.043	.042	3	2
UCEC	Cyclin-B1 →	+0.647	+2.662	.002	<.001	3	2
UCEC	eIF4E →	+0.159	+3.013	.044	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by CRTAM expression — UCEC

Explore this box plot interactively →