CRPPA

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CRPPA mutation is significantly associated with the RNA expression of many other genes, with 980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRPPA-associated genes across cancer lineages are SLC25A5P4, RPL18P1, and EIF3KP3. Each is linked with CRPPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRPPA-to-partner and partner-to-CRPPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRPPA→partner) and Y-score (partner→CRPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSLC25A5P4 →+0.053+4.990.003.00932
COADRPL18P1 →+0.273+4.372<.001<.00132
COADEIF3KP3 →+0.812+3.657<.001.00732
BLCATTTY11 →+0.054+7.640<.001.00932
UCECH3Y1 →+0.693+2.238<.001<.00132
UCECSNORD127 →+0.392+1.879.003.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

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