CRP

Across TCGA patient cohorts, CRP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,654 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CRP-associated GO terms across cancer lineages are Positive regulation of antigen processing and presentation, Plasma membrane organization, and Positive regulation of NF-kappaB transcription factor activity. Each is linked with CRP in more than 7 cancer types. Because this analysis shows association rather than direction, both CRP-to-partner and partner-to-CRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of antigen processing and presentation grouped by CRP-low versus CRP-high in LIHC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRP→partner) and Y-score (partner→CRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Positive regulation of antigen processing and presentation →	+0.061	+2.758	<.001	<.001	3	8
PAAD	Plasma membrane organization →	+0.018	+2.056	<.001	<.001	3	7
PAAD	Positive regulation of NF-kappaB transcription factor activity →	+0.027	+2.294	<.001	<.001	3	7
PAAD	Establishment of skin barrier →	+0.065	+2.345	<.001	<.001	3	7
KIRC	Response to interleukin-4 →	+0.028	+0.603	<.001	<.001	3	7
THYM	Cellular response to interleukin-1 →	+0.036	+0.058	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,654 associations by consensus.

Positive regulation of antigen processing and presentation by CRP expression — LIHC

Explore this box plot interactively →