CRP

Across TCGA pan-cancer cohorts, CRP RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CRP data layer compared with 5 for mutation status.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher CRP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CRP expression acts as an unfavorable survival marker, although some lineages such as ESCA and ACC show a favorable association.

ESCA, LUAD, and KICH are the cancer types where CRP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Quartile	II,III,IV	0.680	0.276	.001	62	view →
LUAD	OS	Median	All	0.760	0.858	.001	53	view →
KICH	OS	Quartile	III,IV	0.178	0.873	<.001	45	view →
KIRC	OS	Median	All	0.528	0.711	<.001	36	view →
BRCA	OS	Median	IV	0.340	0.800	.001	36	view →
KIRP	OS	Quartile	II,III,IV	0.303	0.681	.005	30	view →
HNSC	OS	Median	III,IV	0.425	0.648	.006	27	view →
CESC	DFS	Tertile	IV	0.275	0.616	.025	20	view →
GBM	DFS	Tertile	All	0.131	0.331	.002	18	view →
LGG	OS	Tertile	All	0.377	0.562	.012	15	view →
ACC	DFS	Tertile	IV	0.660	0.113	.004	12	view →
STAD	DFS	Tertile	All	0.266	0.422	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CRP–ESCA (DFS)

Open the ESCA breakdown →