CRP

Across TCGA patient cohorts, CRP mutation is significantly associated with the RNA expression of many other genes, with 1,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRP-associated genes across cancer lineages are NIPA2P2, MRPL39, and ATP5PF. Each is linked with CRP in more than 2 cancer types. Because this analysis shows association rather than direction, both CRP-to-partner and partner-to-CRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPA2P2 grouped by CRP-low versus CRP-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRP→partner) and Y-score (partner→CRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	NIPA2P2 →	+0.054	+5.681	<.001	.001	3	3
SKCM	MRPL39 →	+0.385	+2.328	.005	<.001	3	3
SKCM	ATP5PF →	+0.302	+1.932	.004	.003	3	3
SKCM	RPS10-NUDT3 →	+0.305	+3.743	<.001	<.001	3	2
UCEC	EIF3M →	+0.460	+2.354	.007	.003	3	2
UCEC	OBI1 →	+0.489	+2.815	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,709 associations by consensus.

NIPA2P2 by CRP expression — READ

Explore this box plot interactively →