CRP

Across TCGA patient cohorts, CRP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRP-associated genes across cancer lineages are Notch1, Cyclin-B1, and JNK2. Each is linked with CRP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRP-to-partner and partner-to-CRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CRP-low versus CRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRP→partner) and Y-score (partner→CRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.190	+3.183	.001	.009	3	2
UCEC	Cyclin-B1 →	+0.600	+3.169	.011	.018	3	2
UCEC	JNK2 →	+0.239	+2.469	.004	.010	3	1
UCEC	Ku80 →	+0.246	+2.920	.014	.001	3	1
UCEC	MEK1 →	+0.379	+2.906	.014	.001	3	1
UCEC	PCNA →	+0.269	+2.222	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Notch1 by CRP expression — UCEC

Explore this box plot interactively →