CRP

Across TCGA cell cohorts, CRP RNA expression is significantly associated with the go_rna of many other GO terms, with 723 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CRP-associated GO terms across cancer lineages are Negative regulation of androgen receptor signaling pathway, Regulation of cell fate specification, and Neutral lipid catabolic process. Each is linked with CRP in more than 4 cancer types. Because this analysis shows association rather than direction, both CRP-to-partner and partner-to-CRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of androgen receptor signaling pathway grouped by CRP-low versus CRP-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRP→partner) and Y-score (partner→CRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of androgen receptor signaling pathway →	-0.089	-0.061	.002	.003	3	5
BLOOD_Lymphoma	Regulation of cell fate specification →	-0.134	-0.061	.002	.003	3	3
SOFT_TISSUE	Neutral lipid catabolic process →	-0.076	-0.054	.001	.007	3	3
SOFT_TISSUE	Acylglycerol catabolic process →	-0.076	-0.054	.001	.007	3	3
BONE	Glucose homeostasis →	-0.046	-0.047	.007	.005	3	3
BLOOD_Leukemia	Glycosaminoglycan catabolic process →	+0.073	+0.017	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 723 associations by consensus.

Negative regulation of androgen receptor signaling pathway by CRP expression — BLOOD_Lymphoma

Explore this box plot interactively →