CRP

Across TCGA cell cohorts, CRP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CRP-associated genes across cancer lineages are TBC1D21, CCER1, and PYDC2. Each is linked with CRP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRP-to-partner and partner-to-CRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by CRP-low versus CRP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRP→partner) and Y-score (partner→CRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.145	+5.415	<.001	.004	3	1
LUNG_SCLC	FSHB →	+0.012	+5.029	<.001	.006	3	1
LUNG_SCLC	OR10G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	SPATA31D1 →	+0.843	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TBC1D21 by CRP expression — LARGE_INTESTINE

Explore this box plot interactively →