CROT

Across TCGA pan-cancer cohorts, CROT mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CROT data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CROT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CROT expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where CROT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.742	1.000	.001	23	view →
PDAC	DFS	Tertile	III,IV	0.257	0.691	.029	6	view →
UCEC	DFS	Quartile	All	1.000	0.868	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CROT–LUAD (OS)

Open the LUAD breakdown →