CROT

Across TCGA pan-cancer cohorts, CROT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CROT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CROT RNA is repressed in tumor relative to normal tissue. In most cancer types CROT is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where CROT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CROT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.116	<.001	12	view →
COAD	Female	All	−1.479	<.001	11	view →
THCA	Male	All	−0.797	<.001	10	view →
KICH	Male	II,III,IV	−1.388	<.001	8	view →
STAD	Male	All	−0.882	.010	4	view →
UCEC	All	All	−0.856	<.001	4	view →
KIRP	Male	All	−0.537	.002	4	view →
PAAD	All	All	+0.790	.032	2	view →
READ	Female	All	−0.588	.005	2	view →
PRAD	All	All	−0.459	.001	2	view →
LUSC	All	All	+0.401	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CROT–KIRC

Open the KIRC breakdown →