CROT

Across TCGA patient cohorts, CROT protein abundance is significantly associated with the RNA expression of many other genes, with 7,695 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CROT-associated genes across cancer lineages are TP53TG1, PON2, and SYPL1. Each is linked with CROT in more than 7 cancer types. Because this analysis shows association rather than direction, both CROT-to-partner and partner-to-CROT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CROT versus TP53TG1 in BRCA, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROT→partner) and Y-score (partner→CROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53TG1 →	+0.812	+0.877	<.001	<.001	3	8
UCEC	PON2 →	+0.835	+0.463	<.001	.001	3	5
LSCC	SYPL1 →	+0.688	+0.408	.007	.003	3	5
LSCC	CYB5R1 →	+0.663	+0.441	<.001	.001	3	4
BRCA	UGT8 →	-1.819	-0.819	<.001	<.001	3	4
LSCC	TACSTD2 →	+1.294	+0.505	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,695 associations by consensus.

CROT vs TP53TG1 — BRCA

Explore this scatter interactively →